Pharmacogenetics

Main | Pharmacogenetics

A science at the intersection of medical genetics and pharmacology, which studies the characteristics of the perception of drugs by a person, taking into account his individual genetic factors. All, even the most popular drugs, can be absorbed differently by each person, depending on the presence of special gene variations.

Pharmacogenetic tests make it possible to identify these features in order to select an effective and competent drug therapy in the future.

Sistema BioTech offers the following pharmacogenetics tests:

Genetic sensitivity/ susceptibility to statins

Statins are drugs used to treat cardiovascular disease, lower blood cholesterol levels, dyslipidemias, and atherosclerosis. Despite the widespread use of statin drugs, not all of them are equally effective for each individual. For example, mutations in the SLCO1B1 gene can significantly affect the safety and efficacy of a drug.
Pharmacogenetic research helps to choose the optimal drug, its initial and maximum allowable dosage, as well as to determine the risk of side effects.

Genetic sensitivity /susceptibility to anticoagulants

Anticoagulants are drugs that prevent blood clots by affecting plasma coagulation factors. One of the most popular indirect anticoagulants is Warfarin.
A pharmacogenetic study aimed at determining an individual safe dose of warfarin preparation is carried out for several genetic markers associated with hypersensitivity to warfarin. The result of the analysis is the identification of polymorphisms (genes VKORC1, CYP4F2, GGCX, CYP2C9), which makes it possible to calculate the optimal dose of the drug.

Genetic sensitivity /susceptibility to antiplatelet agents

Antiplatelet agents are a group of drugs that prevent thrombosis. The selection of these drugs should be approached especially carefully in patients with problems of the cardiovascular system. An incorrectly selected drug increases the risk of stroke, myocardial infarction and thrombosis.
Pharmacogenetic testing is widely used in order to correctly select the appropriate drug that will benefit the patient and will not be dangerous for him.

Genetic sensitivity /susceptibility to antipsychotic drugs (antidepressants, antipsychotics, anticonvulsants)

These drugs are aimed at helping people with mental disorders. The use of a pharmacogenetic test is necessary to prevent the development of adverse reactions when prescribing one or more drugs of different pharmacological groups due to their interaction. Preparations, selected taking into account the genetic characteristics of a person, show greater efficiency.
Pharmacogenetic study includes the study of the CYP2D6, CYP2C9, CYP2C19 genes, which are part of the CYP450 superfamily (cytochrome P450).

Genetic sensitivity/susceptibility to proton pump inhibitors

Proton pump inhibitors (PPIs) are a class of drugs that cause a profound and long-lasting decrease in stomach acid production.
Pharmacogenetic research includes the study of the CYP2C19 gene and its polymorphisms. DNA testing allows you to determine the degree of effectiveness of drugs from this group and assess the risk of side effects.

Genetic sensitivity/susceptibility to anti-arrhythmic drugs

Antiarrhythmic drugs are drugs that are used to eliminate and prevent cardiac arrhythmias.
Pharmacogenetic study allows you to determine the risk of side effects when taking antiarrhythmic drugs used for various cardiac arrhythmias, such as extrasystole, atrial fibrillation, paroxysmal tachycardia, ventricular fibrillation.

Genetic sensitivity/susceptibility to hormone replacement therapy drugs and oral contraceptives

Hormone replacement therapy is widely used among different population groups. Pharmacogenetic study provides an answer to the question about the risks of side effects in the long-term use of oral contraceptives and hormone replacement therapy. The study is aimed at searching for mutations in the F2 and F5 genes associated with hereditary thrombophilia, a tendency to increased thrombosis.

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The test results will allow:

prescribe the optimal initial dosage of the drug;

choose the drug with the maximum effectiveness;

avoid drugs that can cause unwanted side effects;

determine the need for closer monitoring during therapy.

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Thus, with the help of pharmacogenetics, you do not have to go a long way in search of a drug, suitable for you personally. With the information about your genetic characteristics the doctor can choose the best possible treatment on the first try and avoid unexpected reactions to the drug.

Pharmacogenetics is a new and rapidly developing science, which holds the future of personalized medicine. Tailoring drugs for patients according to their unique genetic characteristics can one day replace the one-stop approach to drug selection and dosage that is commonly used today.

There is a test to identify the metabolism characteristics of the following groups of drugs: statins, anticoagulants, antiplatelet agents, antidepressants, antipsychotics, anticonvulsants, proton pump inhibitors, antiarrhythmic drugs, hormone replacement therapy drugs.

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