Cardiology
Main | Cardiology
Traditionally, cardiovascular diseases occupy the first place in the structure of mortality. The most common cause of death is coronary heart disease (CHD), which accounts for 16% of total deaths worldwide.
Practice shows that simply going to the doctor annually is not enough to protect yourself from a heart disease. In order to assess the risk of developing life-threatening conditions, as well as to develop an effective prevention scheme, it is necessary to know the genotypic characteristics of a person. Genetic testing by Sistema Biotech helps to solve the problem.
Cardiovascular diseases
Studies of the most common cardiovascular diseases:
Ischemic/coronary heart disease – screening
the study includes the identification of frequent polymorphisms in the APOE gene
Genetic predisposition to cholesterol metabolism disorders — screening
the study includes the determination of frequent polymorphisms in the genes PON1, APOE, APOC3, APOE, PON1, APOB, LPL
Genetic predisposition to the development of atherosclerosis, coronary artery disease, dyslipidemia
the study includes the determination of frequent polymorphisms in the AGT, ACE, NOS3, APOE, ADD1, PON1 genes
Genetic predisposition to myocardial infarction
the study includes the determination of frequent polymorphisms in the genes F2, F5, ITGB3, ACE, NOS3, APOE
Genetic predisposition to dyslipidemia
the study includes the determination of frequent polymorphisms in the genes ADIPOQ, APOC3, APOE, LEPR, MC4R, POMC, NPY, PON1
Genetic predisposition to hypercholesterolemia
the study includes the determination of frequent polymorphisms in the APOB, LDLR, PCSK9, GP1BA, ITGB3, JAK2, SELPLG genes
Thrombophilia
One of the reasons for the development of myocardial infarction, deep vein thrombosis, stroke, and other dangerous conditions is thrombophilia. Thrombophilia is a violation of coagulation (blood clotting), which often leads to the formation of blood clots. This pathology can be congenital or acquired during lifetime. Congenital thrombophilia occurs due to the peculiarities of the genes responsible for the function of blood clotting. Knowing these genetic features, it is possible to raise the primary prevention of cardiovascular diseases to a fundamentally new level.
Sistema-Biotech offers the following tests to detect mutations in the F2 and F5 thrombophilia genes:
Mutations in hemostasis genes
- the study includes the determination of frequent mutations in the genes F2, F5, MTHFR, SERPINE1
Mutations in coagulation system genes
- the study includes the determination of frequent mutations in the genes F2, F5, ITGA2, ITGB3, SERPINE1, FGB, F13A1
Predisposition to thrombophilia (advanced)
- the study includes the determination of frequent polymorphisms in the genes F2, F5, ITGA2, ITGB3, SERPINE1, FGB, F13A1, MTHFR, MTR, MTRR
Plasma factors of the blood coagulation system — screening
- the study includes the determination of frequent polymorphisms in the genes F2, F5, FGB, SERPINE1
A condition in which blood pressure is 140/90 mm Hg. and higher. This disease is the main cardiovascular risk factor for ischemic stroke, coronary heart disease.
Arterial hypertension
The use of molecular genetic methods aimed at identifying and evaluating the genetic risk, predicting the complications of the disease will clarify the treatment regimen and the need for preventive measures to avoid the disease.
Arterial hypertension studies:
Genetic predisposition to develop hypertension
the study includes the determination of frequent polymorphisms in the AGT, ACE, NOS3 genes
Arterial hypertension – screening
the study includes the determination of frequent polymorphisms in the AGT, NOS3 genes
Violations of the functions of the cardiovascular system (endothelial dysfunction)
the study includes the determination of frequent polymorphisms in the genes AGT, ADD1, NOS3, AGTR1, AGTR2, CYP11B2, GNB3
Cardiovascular diseases
Hereditary cardiovascular diseases make a significant contribution to the structure of cardiovascular pathology. The cause of sudden cardiac death (SCD) in young patients under 35 years of age is primary cardiomyopathies or channelopathies in 10−15% of cases.
The extraordinary progress made in the molecular genetics of hereditary cardiovascular diseases makes it possible to identify them at an early stage and determine the management/treatment tactics for these patients and their relatives.
Cardiovascular disease studies:
- Catecholaminergic polymorphic ventricular tachycardia — the study includes the determination of frequent mutations in the RYR2, CASQ2 genes
- Short QT syndrome — the study includes the determination of frequent mutations in the KCNQ1, KCNH2, KCNJ2 genes
- Long QT Syndrome — the study includes the determination of frequent mutations in the KCNH2 gene
- Long QT Syndrome. Brugada Syndrome — the study includes the determination of frequent mutations in the KCNQ1, KCNH2, SCN5A genes
- Sudden coronary death syndrome — the study includes the determination of frequent mutations in the MYH7, TPM1, MYBPC3, TNNT2, KCNH2 genes
- Genetic predisposition to hypertrophic cardiomyopathy — the study includes the determination of frequent mutations in the MYH7, TPM1, MYBPC3, TNNT2 genes
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Hereditary heart diseases
Cardiovascular pathologies are often hereditary. It is important to know the risk of developing cardiovascular diseases for those who have previously had pathological changes on the ECG or lipid spectrum disorders. It is also necessary to determine the genetic predisposition for patients suffering from impaired heart function or heart and vascular defects, as well as people whose close relatives have experienced the following diseases: myocardial infarction, thrombosis, coronary heart disease and other dangerous conditions.
The panel "Hereditary heart diseases" includes an analysis of 219 genes associated with cardiac syndromes.
For example, the study examines ABCC9 gene polymorphisms associated with the development of Cantu syndrome, dilated cardiomyopathy, and atrial fibrillation. It also considers the GJA1 gene, which encodes the integral membrane protein connexin-43, which plays an important role in the synchronization of heartbeats and embryonic development. Mutations in the GJA1 gene are associated with the development of variable erythrokeratoderma of Mendes da Costa, craniometaphyseal dysplasia, hypoplastic left heart syndrome, and syndactyly.
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Sistema-BioTech LLC, 109 235, Moscow, st. 1st Kuryanovskaya, 34, building 11, fl. 5
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License No. LO-77-01-021 654 dated 2021
License No. 77.01.13.001.L.000097.12.21 dated 2021
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