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Plan B: plan not only for the child, but also for his health

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For example, did you know that, according to experts from the World Health Organization, about 50 million couples worldwide (about 7% of the total) are unable to have a child due to male or female infertility. And half of the cases are caused by genetic disorders. In 30% of cases, genetic infertility is detected in the woman.

Scientists know several thousand genes that affect female and male reproductive function.
If there is a mutation, that is, a change in genes, then the chances of a successful pregnancy decrease. Genetic changes include:

The result of a genetic study can serve as the basis for the prevention of this disease, as well as for the correction of the current treatment of infertility in the patient.

Although a person has many genes, a mutation of a single one can cause irreparable consequences: missed abortion, complications in childbirth, developmental delays in a child. Such mutations are not very common. Usually, a person has a combination of several "weak" mutations, but together they can also affect reproductive health.

Knowing what specific mutations a woman and her partner have, much can be done.
For example, with Leiden mutations in a woman, drugs that reduce the risk of premature birth and increase the likelihood of implantation are prescribed at the planning stage. Without a genetic study, it would be difficult to establish the cause of the non-occurrence of pregnancy, because very often serious genetic mutations are present in outwardly and physically healthy people.

Thus, endometriosis becomes the cause of infertility in 30−50% of cases. In other words: every 10th woman will have difficulty conceiving due to the estrogen dysfunction.

In endometriosis, eggs cannot pass through the fallopian tube and die. However, doctors know how to deal with this problem, it is crucial to identify it. A genetic test can show a tendency to specific hormonal disorders.

Genetic mutations sound scary. It’s starting to feel like the only chance to be a parent is IVF. But it’s not. Genes may not always be directly related to reproductive health. For example, some gene abnormalities may indicate poor sensitivity to vitamin D or a tendency to insulin resistance. Seemingly insignificant, but if there are many such mutations, the chances of conceiving are dramatically reduced. Hopefully, it can be remedied! Knowing your own characteristics, you can prepare for motherhood by removing all the deficits. Sometimes this is enough to get pregnant. Competent reproductologists always start with a basic health check. Deficient mother = deficient child. After all, it is important not just to get pregnant, but to safely carry the pregnancy and give birth to a healthy child.

But there are cases when it is impossible to do without IVF. And here genetics again helps to build the right treatment tactics. And it’s not just about dangerous genetic diseases that are passed on to the child. Problems can arise much earlier, for example, at the stage of embryo implantation. Everything can go smoothly in the IVF protocol: hormonal stimulation of ovulation, egg retrieval, fertilization, obtaining healthy embryos of excellent quality. But pregnancy does not occur: the embryo simply does not attach to the endometrium. Not only the embryo is responsible for the success of implantation, but also the endometrium — the inner layer of the uterus. The immaturity of the endometrium, as well as chromosomal changes in the cells of the embryo, are considered to be one of the main reasons for IVF failure. In about 25% of women who have experienced the implantation failure, a genetic test reveals a shift in the implantation window. This means that the period of maximum maturity of the endometrium occurs a little earlier or later than the usual period. Without knowing this nuance, you can unsuccessfully transfer embryos into the uterine cavity again and again, conduct stimulation, modify the drug doses … Or you can pass a genetic test once and know exactly what to pay attention to.

PreMama’s DNA genetic study is a detailed report on a woman’s individual characteristics and her reproductive health. Just one analysis will help answer a lot of questions:

— o whether the woman has dangerous genetic mutations;

— o what should be changed in everyday life to increase the chances of pregnancy;

—o whether there is a tendency to infertility, and what could the reason be;

— o how egg quality can be improved on the basis of the report.

A DNA test can be taken not only to check if everything is fine with your health, but also in order to maximize the effectiveness of the IVF procedure if you are already struggling with infertility. Knowing the features of your genetics, you can achieve the result.

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