Sistema Biotech has developed genetic tests to assess the reproductive health of a couple: PreMama, PrePapa.

DNA test for genetic predisposition to uterine fibroids.

Uterine fibroids are nodular benign tumors that develop in the muscular layer of the uterine wall. According to statistics, this is one of the most common tumors of the reproductive apparatus and in 25% of cases is the cause of infertility in women.

DNA test for genetic predisposition to early development of uterine fibroids.

Usually, uterine fibroids occur in women after the age of 35−40. But the presence of certain genes can provoke the early appearance of this neoplasm. The study includes the determination of frequent polymorphisms in the CYP1A1, CYP17A1, COMT genes.

DNA test for genetic predisposition to the development of complications in long-term hormonal contraception.

with estrogen-containing and combined drugs.

The study includes the determination of frequent mutations in the F5, F2, BRCA1, BRCA2 genes.

DNA test for genetic predisposition to implantation disorders.

Implantation is the attachment of an embryo to the lining of the uterus. Successful implantation depends not only on the quality of the embryo itself, but also on the maturity of the endometrium, that is, the readiness of the uterine mucosa to accept the developing embryo. It is often at this stage that difficulties arise and pregnancy does not occur. But now reproductive specialists know how to avoid this problem and make sure that the embryo is securely “fixed” in the uterus. The study includes the determination of frequent polymorphisms in the TP53, LIF, MDM4, MDM2, USP7, ESR1, TNF genes.

DNA test for genetic predisposition to the occurrence of defects in folate cycle enzymes.

According to experts in the field of obstetrics and gynecology, only about 30−50% of pregnancies proceed physiologically normally, and this percentage is constantly decreasing. The most common complications during pregnancy, apart from early toxicosis, are miscarriages, which end up to 15−20% of pregnancies, and premature births (6−10%). Approximately 8% of pregnant women develop oligohydramnios, 3−8% - preeclampsia and eclampsia, 2−14% - gestational diabetes mellitus. It is possible to find out the tendency to the appearance of these features of the course of pregnancy even at the stage of planning a child. The study includes the determination of frequent polymorphisms in the MTHFR, MTR, MTRR genes.

DNA test for genetic predisposition to pregnancy complications and fetal pathology.

The study includes determining the risks of neural tube defects, fetoplacental insufficiency, fetal growth retardation, placental abruption, preeclampsia, preembryonic and embryonic loss. The study includes the determination of frequent polymorphisms in the AGT, NOS3, MTHFR, MTR, MTRR, FGB, F5, F2, SERPINE1 genes.

DNA test for genetic predisposition to miscarriage due to endothelial dysfunction (APLS, preeclampsia).

The study includes the determination of frequent polymorphisms in the F5, F2, MTHFR, CYP17A1, SERPINE1, ACE, F13A1 genes.

DNA test for genetic predisposition to thrombophilia.

Thrombophilia during pregnancy, according to statistics, is the cause of habitual miscarriage in 17% of cases and the reason to address the doctor for women with the problem of spontaneous miscarriages. This study includes the determination of frequent polymorphisms in the F5, F2, F7, FGB, MTHFR, MTR, MTRR, ITGA2, ITGB3, AGT, ACE, NOS3, ESR1 genes.

DNA test for genetic predisposition to gestoses and preeclampsia.

Preeclampsia and gestoses are complications that occur in late pregnancy in 3−8% of cases. These diseases can provoke premature birth. The study includes the determination of frequent polymorphisms in the F5, F2, NOS3, AGT, SERPINE1 genes.

DNA test for genetic predisposition to polycystic ovary syndrome.

Polycystic disease (PCOS) is a hormonal disorder in which cysts (immature eggs) accumulate in the ovaries, and the ovaries themselves can increase in size up to 5 times. PCOS can block ovulation, cause an unstable menstrual cycle, and prevent pregnancy. The study examines polymorphisms in the INS, PPAR-y, CYP11A1, and AR gene.

DNA test for genetic predisposition to hirsutism and hyperandrogenism.

Hyperandrogenism in women is a group of endocrinopathies characterized by excessive secretion or high activity of male sex hormones in the female body. Manifestations of various syndromes, similar in symptoms, but different in pathogenesis, are metabolic, menstrual and reproductive disorders, androgenic dermopathy (seborrhea, acne, hirsutism, alopecia). The study includes the determination of frequent polymorphisms in the CYP21A2, CYP17A1, INS, FSHR, SRD5A2 genes.

DNA test for genetic predisposition to hyperandrogenism and polycystic ovary syndrome (PCOS).

Often these diseases occur in combination. The study includes the determination of frequent polymorphisms in the ADIPOQ, AR, CYP11A1, CYP17A1, CYP21A2, DENND1A, FSHB, FSHR, INS, LHCGR, MTNR1B, PPARG, SRD5A2 genes.

DNA test for genetic predisposition to infertility in men.

The study is based on the analysis of mutations in the CFTR gene and microdeletions of the Y chromosome. The integrity of the Y-chromosome is a necessary condition for the normal structure and functioning of the male reproductive system. Mutations of the CFTR gene can lead to the development of obstructive azoospermia — the absence of sperm in the seminal fluid due to bilateral obstruction of the vas deferens, and cause male infertility.